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Combine the biscuit mix and water and spread in a lightly greased 13x9 baking dish.
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Bake uncovered at 375° for 9 minutes.
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Remove from oven and set aside.
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Brown and drain the ground beef.
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Add the taco seasoning, tomato sauce and garlic powder.
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Spread mixture over crust.
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Combine the sour cream, cheese and mayo.
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Spoon over ground beef mixture and sprinkle with paprika.
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Bake uncovered at 375° for 25 more minutes.
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Once done, cut into squares and top each piece with your favorite toppings.